| 2003-10-12 10:05:42
| #immortal from 2003-10-12 06::00 (showing messages 181-240) Bookmark the permanent url.
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| 10:05:42 | caliban | link to chat topic: http://imminst.org/forum/index.php?s=&act=ST&f=114&t=1857&st=0 |
| 10:06:08 | prometheus | Aubrey. I see that you have powerpoint files and audio files available. Will they remain so indefinitely? |
| 10:06:15 | ag24 | sorry - I'm new to thisa - what should I do with that link, if anything? |
| 10:06:33 | ag24 | ppt and audio - yes I think I can keep them up indefinitely. |
| 10:06:43 | kevin | Ag.. you can just click on it and it should bring up a browser window with your interview with BJ in it.. |
| 10:06:51 | Bluesteel | What reaction have you had to your 'WILT alternative' as proposed at IABG 10? It seemed very radical... |
| 10:07:03 | caliban | the link is just for the information of others... a primer |
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| 10:08:20 | ag24 | WILT: very heartening. Initially I have been frustrated that most people hang up on the feasibility of the stem cell transplantation |
| 10:08:50 | ag24 | but at the conference and since then, most discussions have been about whether it is ambitiuos enough. |
| 10:09:24 | ag24 | There is a lot of concern -- which I very much share -- that ALT is more dangerous than it may look and that it may not be amenable to gene deletion as easily as telomerase is. |
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| 10:10:21 | Bluesteel | Those I spoke too were more concerned over the regular procedure necessary, more than the feasibility |
| 10:10:47 | ag24 | That's ointeresting. (Hm, I've just discovered that backspace doesn't work in this...) |
| 10:11:13 | ag24 | Yes, I think the feasibility of the therapy does come down to the frequency. |
| 10:11:29 | ag24 | and of course the sheer nastiness of it! |
| 10:11:35 | Bluesteel | And the expense.... |
| 10:11:42 | ag24 | but that can be improved by degrees. |
| 10:11:48 | ag24 | and so can the expense. |
| 10:11:57 | kevin | Is the ALT-ernative pathway really that dangerous.. ? and can we not produce apoptosis mechanisms with gene therapy to take care of cells.. ? And what about the telomerase vaccine of Geron?..w ould that not be a feasible alternative to stem cell transplantation? |
| 10:12:36 | ag24 | The people swho focus more on the ALT problem are ones that I've already convinced that the stem cell part may be doable tolerably in the 10-20 year timeframe that I'm discussing. |
| 10:13:20 | ag24 | to answer kevin - I very much buy all these approaches, which is why I invited the top people pursuing them to the nmeeting, but Ithink they won't be powerful enough. |
| 10:13:38 | caliban | Taking each day individually, which presentations do you think made the greatest impact? |
| 10:13:52 | ag24 | The problem is as I said in the talk -- these therapiers can all be "escaped" too easily, but turning one or two well-chosen genes on or off. |
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| 10:14:26 | ag24 | wow, hard question! I think every day had a big impact in defferent ways and on different peope. |
| 10:14:46 | ag24 | On the foirst day I know a lot of people were blown away by Brockes's newts. |
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| 10:15:02 | kevin | Yes.. I understand that mutations make cells almost infinitely flexible in trying to escape death on their own scale.. |
| 10:15:08 | ag24 | On day 2 I like to think I impressed (or at least annoyed!) people a lot. |
| 10:15:27 | kevin | Rosenthal and Brocke made my mouth jaw drop.. |
| 10:15:31 | ag24 | On day 3 it was definitely John Archer who made the biggest impression -- he has been fending off interested people ever since |
| 10:15:59 | ag24 | on day 4 I think Stock and Haseltime both got pepole thinking a lot. |
| 10:16:01 | MichaelA | hm, the overall optimism at that conference seemed amazing |
| 10:16:22 | ag24 | that was my plan - get people to educate each other. |
| 10:16:34 | ag24 | everyone is optimistic about the rate of progress in their own field |
| 10:16:49 | ag24 | but they assume by default that everyone else ois having a harder time! |
| 10:17:09 | Bluesteel | I got the impression that all had moved from an 'if' to a 'when' as far as SENS is concerned |
| 10:17:33 | ag24 | Certainly not "all" -- but certainly a sufficient proportion to make me very confident. |
| 10:17:43 | Bluesteel | Which was more than I had expected |
| 10:18:00 | ag24 | That was the thing that struck me most about the discussion after the ethics session: |
| 10:18:04 | kevin | Everyone seemed very tentatively eager to hope.. |
| 10:18:28 | ag24 | even though a large majority of those present said we should not be talking about timescales for hiuman life extension, |
| 10:18:47 | ag24 | they were not prepaered to say I was wrong about mouser rejuvenation within 10 years. |
| 10:18:55 | MichaelA | heh |
| 10:18:59 | kevin | Caplan's talk spoke directly to that feeling.. that life-extension was on the defensive |
| 10:19:01 | MichaelA | a silent consensus |
| 10:19:24 | ag24 | I think that any biogerontologist who holds both those views is one who has not come to terms with their responsibilities to society |
| 10:19:37 | MichaelA | that is unfortunate |
| 10:19:47 | MichaelA | because there is a profound humanitarian responsibility involved |
| 10:19:56 | kevin | and Will Haseltine at that session asked him what would happen if we were discussing immortality instead of just life-extension.. |
| 10:19:56 | MichaelA | have you received any negative media coverage thus far? |
| 10:19:57 | ag24 | No, not unfortunate - it' s just that they hadn't had time to digest it. |
| 10:20:05 | caliban | How was the press coverage? |
| 10:20:26 | ag24 | I think very few peope, arrived in Cambridge agreeing with me about the 10-year timeframe for robust mouse rejuvenation |
| 10:20:49 | ag24 | negative media - basically none. In fact absolutely none in actual media per se, just a few emails |
| 10:21:12 | prometheus | That is a tragedy. |
| 10:21:15 | ag24 | press coverage was not as extensive as I was hoping for, but it's persisting - I'm doing a lot of interviews at the omoment |
